Durability and bio-compatibility

OSSIX Plus membrane creates a barrier that lets in nutrients, but keeps out epithelial cells.3

Human Histology 4-6 Months Post-op

Image of human histology 4-6 months post-op - new bone & OSSIX PLUS®
Image of human histology 4-6 months post-op - bone graft, new bone & OSSIX PLUS®
Image of human histology 4-6 months post-op - OSSIX PLUS® & ossified membrane
Image of human histology 4-6 months post-op - OSSIX PLUS®, new bone & OSSIX PLUS®

Clinically proven

With over 100 scientific publications, this resorbable collagen membrane has been used in hundreds of thousands of cases for over a decade.

See more studies
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To order any OSSIX product, call OraPharma at 866-273-7846

*Preclinical study using animal subjects.

REFERENCES: 1. Zubery Y, Goldlust A, Alves A, Nir E. Ossification of a novel cross-linked porcine collagen barrier in guided bone regeneration in dogs. J Periodontol. 2007;78(1):112-121. 2. Neiva R, Pagni G, Duarte F, et al. Analysis of tissue neogenesis in extraction sockets treated with guided bone regeneration: clinical, histologic, and micro-CT results. Int J Periodontics Restorative Dent. 2011;31(5):457-469. 3. Friedmann A, Dehnhardt J, Kleber BM, Bernimoulin JP. Cytobiocompatibility of collagen and ePTFE membranes on osteoblast-like cells in vitro. J Biomed Mater Res A. 2008;86(4):935-941.


OSSIX Plus® biodegradable collagen membrane is intended for use during the process of guided tissue regeneration (GTR) and guided bone regeneration (GBR) as a biodegradable barrier.

Important safety Information:

  • OSSIX Plus® must not be used in:
    • Patients with known collagen hypersensitivity
    • Patients with a sensitivity to porcine-derived materials
    • Patients suffering from autoimmune disease and connective tissue disease, such as systemic lupus erythematosus, dermatomyositis, etc.
  • OSSIX Plus® is intended for use as a single use device. Do not resterilize.
  • Treatment of high risk patients, such as smokers and patients with uncontrolled diabetes or periodontal disease, may be impaired. Infection control and good oral hygiene should be achieved prior to surgical intervention.
  • Clinical and post marketing experience with OSSIX Plus® reveals an excellent safety profile. Adverse reactions with OSSIX Plus® were not observed. Yet, as the membrane is of a collagen origin, allergic reactions (e.g., erythema, swelling, induration and/or pruritus at treatment site) may not be entirely excluded.

Please see accompanying Instructions for Use Click here for Instructions for Use.